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65,66,67 Although the risk factors for PDPN are poorly understood, female sex, longer diabetes duration, increased neuropathy severity, renal dysfunction, higher HbA1c levels, and higher BMI have been suggested as contributing factors

Seventy five non-smoking, H.pylori -positive, endoscopically diagnosed, male cases with duodenal ulcer and 15 healthy H.pylori -negative, male controls with a matched age (25-50 years) and a body mass index (22.480.67 Kg/m2) were recruited in the present study

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In 1902, Bayliss and Starling identified secretin, the first gut hormone proof that the intestine sends chemical signals to other organs