Increased epigenetic marks (H3K27ac, H3K4me3, H3K4me1) were associated with primed-microglia in Parkinson's disease (Huang et al., 2023) and AD (Wendeln et al., 2018), and glycolysis/H4K12la/PKM2 positive feedback loop exacerbated microglial dysfunction (Pan et al., 2022)
M., Hanson, P., Weickert, M
2014 Beck DE, Sweeney WB, McCarter MD publish a multicenter, double-blind, placebo-controlled trial in International Journal of Colorectal Disease
Social anxiety disorder Zoloft is FDA-approved for social anxiety disorder
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Orforglipron delivers up to 27 lb weight loss in pivotal Phase 3 trial (ATTAIN-1)