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Emerging evidence from key clinical trials highlights their multifaceted roles across various physiological systems, including cardiovascular, renal, hepatic, and neurological domains, as shown in Figure 3

Stirban AO, Andjelkovic M, Heise T et al (2016) Aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma agonist, improves insulin sensitivity, glucose control and lipid levels in people with type 2 diabetes: findings from a randomized, double-blind trial

Development 142 , 25542563 (2015)

Defective cell cycle regulation and pro-survival mechanisms may result in the propagation of mutations that contribute to the development of cancer

Drug-induced Liver Injury