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This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months

Previous research has demonstrated that oxalate crystals cause ongoing damage to RTCs, triggering inflammatory responses closely linked to kidney stone formation

King WC, Chen JY, Belle SH, Courcoulas AP, Dakin GF, Elder KA, et al

Mazdutide, orforglipron, and related agents have different mechanisms, routes, and development paths