Cell culture studies show stimulation of beta-3 adrenergic receptors in adipocytes, increasing fat oxidation while inhibiting lipogenesis through acetyl CoA carboxylase blockade
If needed, metabolic markers like methylmalonic acid (MMA) or homocysteine can indicate how well your body is using B12
But actual results can vary based on an individual: Talk with your doctor to determine a realistic timeline after factoring in your attributes and risk factors
If you have a B12 deficiency then B12 shots are a good option for you
Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71
This mechanism is not fully elucidated and it is possible that it acts via the IGF-1 receptor (not GHR) in localized concentrations
