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JHU083 JHU083 is a prodrug form of L-DON designed to be cleaved by tissue proteases and other enzymes in the cancer, thereby limiting its effects on other organs [87, 102] (Fig

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The high fiber content can help prevent constipation, a common GLP-1 side effect

Adjusting one hormone pathway inevitably affects others, which is why a holistic approach to managing side effects, rather than targeting fatigue alone, produces better outcomes

doi: 10.1016/j.jdermsci.2023.04.006

Mechanism plausible from animal data