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Structure Therapeutics: GSBR-1290 [60] [61] [60] [61] An oral GLP1R agonist, currently being studied in a double-blinded, placebo-controlled Phase 2a clinical trial

What Happens After FDA Approval Even after FDA approval, there are several steps before retatrutide becomes widely available: Prescriptions and Availability Lilly will need to scale manufacturing, which typically begins well before approval Initial supply may be limited, similar to the early availability challenges seen with Mounjaro and Zepbound Prescriptions will initially require an in-person or telehealth consultation with a licensed provider Insurance Coverage Insurance coverage is not automatic upon FDA approval Private insurers will set their own coverage policies, which can take months to finalize Medicare and Medicaid coverage depends on the approved indication and ongoing policy decisions The Medicare Inflation Reduction Act drug price negotiation program may eventually apply Pricing Context Current GLP-1 drug pricing provides context for what retatrutide might cost, though Lilly has not announced pricing: GoodRx has offered introductory pricing of $199/month for certain GLP-1 medications

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If MHRA approval arrives in late 2027 to mid-2028, private availability could follow within weeks, as it did with Mounjaro and Wegovy

Before starting Zepbound or Wegovy, talk with your doctor if any of the following conditions or health factors apply to you: if youve ever had an allergic reaction to either drug or any of its ingredients if youre pregnant or planning to become pregnant if youre breastfeeding or planning to breastfeed if you have diabetic retinopathy (an eye condition) if you have a pancreas problem if you have severe gastroparesis (a stomach condition) if you have type 2 diabetes if you have a kidney problem if you have a surgery or medical procedure planned To learn more about either drug, see this Zepbound overview and this Wegovy overview