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That range comes from equine practice, not human dose-finding

Although raised homocysteine levels might be partly due to a poor vitamin B 12 status, the latter was not related to risk of dementia or Alzheimer's disease in this study (73)

W., Coomarasamy, A., & Khan, K

In addition, several agents are in mid- or late-stage development for chronic diseases such as peripheral artery disease and atherosclerotic heart disease, which disproportionately affect individuals with SMIs

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