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Since the follow-up duration of the two studies were different (15.9 months vs

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14 In the SURMOUNT 1 trial, tirzepatide 15 mg/wk with general nutritional instructions produced a 20.9% reduction in body weight from baseline (versus 3.1% with general nutrition instructions alone), 15 whereas in the SURMOUNT 3 trial, tirzepatide 10 or 15 mg/wk started after 12 weeks of intensive lifestyle intervention produced a 25% reduction from baseline (versus 4.8% with intensive lifestyle intervention alone)

Contribution statement MH and NP designed/performed the analyses, discussed the findings and drafted the manuscript

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