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Diet Recommendations for MC1R rs1805007 and the Melanotan-1 Pathway A targeted nutritional approach for the MC1R rs1805007 variant focuses on supplying the micronutrients and macronutrient balance that support collagen synthesis, skin repair, and cellular renewal and reduce the metabolic burden on pathways connected to Melanotan-1

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It is a well-researched compound in pigmentation, photoprotection, and neuroendocrine modulation studies

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As a master transcriptional factor, nuclear factor erythroid 2-related factor 2 (NRF2) plays a key role in the regulation of an extensive panel of antioxidant response elements (ARE)-related genes including superoxide dismutase (SOD), catalase (CAT), glutamate-cysteine ligase catalytic subunit (GCLC) and glutamatecysteine ligase regulatory subunit (GCLM), NAD(P)H: quinone oxidoreductase-1 (NQO-1) and heme-oxygenase-1 (HO-1) 7,8