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In clinical trials of semaglutide 2.4 mg used for weight management with lifestyle intervention, average losses were substantial over many months

Biochemical and biophysical research communications 422 , 2227, doi:10.1016/j.bbrc.2012.04.087 (2012)

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For example, a patient with a BMI of 35 kg/m who has anovulatory cycles could undergo 3 to 6 months of GLP-1 guided weight loss, then try to conceive once metabolic markers normalize

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