X.WerneckeJ.et al
10 The American College of Cardiology/American Heart Association primary prevention of cardiovascular disease guideline supports the use of GLP-1 RAs in patients with T2D and high atherosclerotic CVD risk, but does not mention existing HF
The rats were acclimatized in a controlled environment at 22 1 C with a 12/12 h light/dark cycle, with unlimited access to food and water, for two weeks prior to the experiments
J Mater Civ Eng 31(2):04018389
This review highlights a variety of scaffolds with high DPP-4 inhibition activity, such as pyrazolopyrimidine, tetrahydro pyridopyrimidine, uracil-based benzoic acid and esters, triazole-based, fluorophenyl-based, glycinamide, glycolamide, -carbonyl 1,2,4-triazole, and quinazoline motifs
Radiolabel studies suggest small peptides like exenatide and lixisenatide cross the BBB, while acylated or PEGylated analogues (liraglutide, semaglutide, NLY01) show minimal uptake