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This framework is a practical lens

The hormone then acts on multiple target tissues: it stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppresses glucagon release from alpha cells, slows gastric emptying , and promotes satiety through central nervous system pathways

Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1

In the somatotropic axis, both pathways converge at the level of pituitary somatotropes, but the intracellular signaling mechanisms are different Ipamorelin stimulates the Gq/Ca2+ pathway, and CJC-1295 the Gs/cAMP pathway

A., Bakaloudi, D

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