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Brain 145 , 35823593 (2022)

For drugs with intracellular targets, it is important that after reaching the brain ECF, the drug crosses the cellular membrane of the brain parenchymal cells via a transporter expressed in the target cells

The molecular axis constituted by System Xc GSHGPX4 and its dysregulation in OA have been repeatedly verified and confirmed in multiple independent studies, establishing it as a closely watched potential therapeutic target for intervening in ferroptosis (Figure 1)

identified 428 ICD-10 conditions as co-occurring in individuals with FAS

Unbalanced oxidative stress and ROS-produced collagen damage to amniotic membranes are involved not only in PTB but also in premature preterm rupture of membranes (PPROM) [15]

Ventura-Clapier, R., Garnier, A