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Tissue was obtained with regulated informed consent from all individuals by the UoB Ethical Tissue Bank (an ethically approved human research tissue bank, licensed by the Human Tissue Authority (HTA), Licence number: 12191) with approval from the National Research Ethics Service (NRES) Committee Yorkshire & The HumberLeeds East (approval number 17/YH/0086)

The primary limitation relates to the modest sample size and short intervention duration, which may limit precision and long-term inference but does not substantially undermine internal validity under JBI criteria

A high-salt diet mechanistically increases intestinal permeability and pro-inflammatory cytokines in human and animal research, promoting local and systemic tissue inflammation (164, 168, 169)

Switching from one to another rarely eliminates them

People who follow it as written report a very different experience

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