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BPC-157: Discovery and Regulatory History How BPC-157 traveled from a 1993 gastric-cytoprotection hypothesis at the University of Zagreb, through Pliva's PL14736 clinical program, to research-use-only status and a 2022 WADA Monitoring Program listing

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830 There is evidence to suggest that the His in the Cys- His motif in HypB (Figure 38B) toggles on and off the Ni II as a function of nucleotide status as an important aspect of the gating process, but more needs to be done here

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However, extremely high levels may indicate an underlying condition such as liver disease, kidney disease, or certain types of cancer