From there, dosage may be increased in 2.5 mg increments after a minimum of four weeks at each level
Clinical outcomes by dose level The SURMOUNT-1 clinical trial, published in the New England Journal of Medicine, enrolled 2,539 adults with obesity or overweight
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TRIUMPH-4 also tested a 9mg dose, and additional trials are evaluating a 4mg maintenance dose
Interaction studies have shown no clinically meaningful effects with tested oral medicines (such as paracetamol, oral contraceptives, lisinopril, digoxin, atorvastatin, and griseofulvin), though antibiotics were not specifically studied
The good news is that the GLP-1 medication landscape has expanded significantly