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The fourth level describes impaired mitochondrial functions (integrated processes involving multiple mitochondrial components), such as decreased ATP synthesis, increased ROS emission, dysregulated calcium regulation, and altered steroidogenesis

Corticosteroids, IVIG, cyclosporine, TNF- inhibitors, and plasma exchange have some beneficial effects on mitigating skin lesions [26], while the evidence for lowering mortality remains controversial

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The cytokine storm in COVID-19 is an exaggerated immune response characterized by the excessive synthesis of pro-inflammatory cytokines, potentially resulting in ARDS and multi-organ failure

None of the folate biofortified crops has been approved for commercial release

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