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For those following the development of retatrutide with a view to future use, it is worth noting that NICE guidance on obesity pharmacotherapy including its technology appraisal of semaglutide (Wegovy) for weight management does not specify a preferred time of day for weekly injectable agents
To avoid frequent flip-flopping, we believe it is ethically justified for the FDA to require a greater burden of proof, or a greater level of certainty provided by the evidence at hand, to justify removal of a boxed warning than it did to impose one, they wrote
Scientific References GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists: strengthened warnings on acute pancreatitis, including necrotising and fatal cases
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