At the beginning of their illness, many patients report feeling exhausted, yet also strangely wired. The wired feeling is the slight shift towards seizure that occurs as a result of the excitatory neurotoxicity. From Carol Sieverlings reports Cheney proposed that overly activated NMDA (glutamate) receptors cause neurons to fire at the slightest stimulation
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Since these pathogen proteins and metabolites are often similarly structured to ones created by the human host, such molecular mimicry makes it difficult for the host to recognise the foreign pathogen (193), resulting in the hosts immune system becoming increasingly sluggish and more susceptible to acquiring other infectious agents