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References 1 AboonabiA.McCauleyM

Dose titration is not necessary for CKD or CHF

Studies in obese rodents fed high-fat diets for extended periods show that diminished carnitine reserves in skeletal muscle are accompanied by marked perturbations in mitochondrial fuel metabolism, including reduced complete fatty acid oxidation, elevated incomplete -oxidation, and impaired substrate switching from fatty acid to pyruvate oxidation

As a consequence, an increase in appetite causes fat accumulation and weight gaincommon observations in high-pressure jobs

Vadim Sherman, medical director of bariatric and metabolic surgery at Houston Methodist Hospital