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Research indicates that RPE cells from individuals with AMD exhibit elevated ROS levels and an increased susceptibility to oxidative stress compared to RPE cells from non-AMD donors [421]

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Poor nutrition, stress, and toxins can reduce its levels

[24:29] Lactoferrin also has directly a bacterial static effect, which means that it kills the bacteria themselves by destroying their cell walls

From a morphological point of view, iron-intoxicated cells exhibit certain characteristics such as small mitochondria, condensed mitochondrial membrane density, reduced or absent mitochondrial cristae, and ruptured outer mitochondrial membranes (13, 26)

Treatments that promote synaptic restoration, such as ketamine, ECT, glutamate modulators, cholinergic agents, anti-inflammatory strategies, and epigenetic interventions, may offer greater efficacy