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A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice

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Small-angle X-ray scattering, rheological techniques, laser scanning confocal fluorescence microscopy, and in vitro release studies showed that the addition of an appropriate amount of lipophilic drug to the hexagonal phase liquid crystal gel enhanced the permeability of the hydrophilic drug while slowing down the release of both drugs, thereby prolonging the drug retention time and improving local bioavailability (179)