Who is a good candidate
Microbiome mediation is untested : gut microbiome changes with GLP-1 therapy are documented, but direct consequences for the vaginal microbiome and infection risk in semaglutide users are not established
However, whether these effects occur in humans remains unknown
Safety really comes down to proper dosing and patient selection by a licensed provider. A 2025 review that assessed the safety profiles of both drugs found that the most common adverse effects are the same for both tirzepatide and semaglutide, namely, nausea, vomiting and diarrhea
The cost difference makes treatment accessible to people who otherwise couldnt afford brand-name prices
New JAMA Study Links Wegovy to NAION A JAMA study published on July 3, 2024, on the Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide found an increased risk of the condition in patients taking semaglutide compared to those taking non-GLP-1 RA medications