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Using complex CRC GEMMs with proficient immune signalling, we demonstrate an increase in cell death and survival in these heterogeneous tumours, more akin to a tumour histology than xenograft or PDX counterparts 21,78

It is naturally produced in liver cells by combining three amino acidsglutamine, glycine, and cysteinebut can also come from food sources 1

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Studies have also reported that DSIP stimulates the release of luteinising hormone (LH) and somatotropin (growth hormone), while inhibiting somatostatin indicating a broader endocrine regulatory role that extends beyond the stress axis