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Mechanism of age-associated up-regulation in macrophage PGE2 synthesis

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The inactive structure of GLP-1R presented here aligns nicely with a possible role of the GLP-1R ECD as a negative regulator of GLP-1R, although, in contrast to GCGR, we and others have failed to identify mutations in the ECD/ECL interface that increase basal activity of GLP-1R

10.1074/jbc.M007597200 132 ShivakumarA.Yogendra KumarM

Oxidative stress is controlled very tightly in the thyroid gland via the synthesis of glutathione peroxidase, which can safely inactivate sources of oxidative stress, such as hydrogen peroxide and free radicals

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