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La secrecin de GLP-1 sigue un patrn bifsico tras la ingesta de alimentos: una fase temprana que ocurre minutos despus de comer, mediada por seales neurales y hormonales, y una fase tarda ms prolongada cuando los nutrientes alcanzan directamente las clulas L del intestino distal

4244 Recently, a single cell gene expression-based informatics approach identified pacemaker cells as cellular targets for GLP-1 RAs, 44 suggesting that at least part of the positive chronotropic effect may be mediated through the sinus node

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