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Retatrutide (LY3437943): This is a formidable research peptide, a novel agonist for three key receptors: the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors

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One small study (12 patients) showed a 58% response rate for knee pain relief

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It also supports experiments on how the peptide interacts with fat-rich environments in lab models