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Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk

Semaglutide significantly reduced fasting insulin, but not fasting blood glucose

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NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)

High-fat and high-sugar foods, for example, may trigger nausea or other digestive issues