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Since GSH plays a key role in oxidative stress suppression, ferroptosis suppression, and aldehyde detoxification, persistent or high consumption of tissue GSH may promote ferroptosis in ALDH2*2 individuals, suggesting crosstalk between aldehyde metabolism and ferroptosis pathways

Moreover, homocysteine alters anticoagulant effectors such as the thrombomodulin/protein C system and antithrombin III

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Due to their highly reactive nature, ROS promote the oxidation of proteins, DNA, and lipids, ultimately disrupting cellular function and viability [242]

Appetite suppression often begins within the first week