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All treatments are prescribed after a consultation to ensure safety and effectiveness

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Until such data are available, prescribing decisions should be individualised and based on careful assessment of risks and benefits

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Liver biopsies from MASH patients and M1 macrophage with the PNPLA3 I148M variant revealed reduced PGC1-alpha, NRF1/2, mt-ND1, and 16sRNA mRNA transcripts compared to wildtype

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Among the 4,076 participants, 80% were receiving ACE inhibitors, ARBs, or angiotensin receptor-neprilysin inhibitors, and 15.2% were on SGLT2 inhibitors

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Tirzepatide demonstrated remarkable weight-reducing efficacy in randomized controlled trials such as SURMOUNT-1 and SURMOUNT-2, with mean body-weight reductions ranging from 15 to 22.5% (32, 33)

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