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It is administered as per doctors schedule

Herington AC, Ymer S, Stevenson J

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Do not freeze the injections

doi: 10.1038/s41598-018-22927-0

In addition, elevated levels of proinflammatory cytokines IL-6 and IL-12 and impaired intestinal barrier function increase permeability, allowing harmful substances like lipopolysaccharides to translocate into the bloodstream