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Another trial did not find creatine monohydrate to be efficacious compared to placebo in treating bipolar depression, but creatine monohydrate performed better than placebo when remission criteria were considered [65]

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In addition, ROS mediate cysteine sulfenylation of another ER stress sensor, inositol requiring enzyme 1 (IRE1), which activates nuclear factor-E2-related factor-2 (Nrf2) to generate an antioxidative response (Hourihan et al., 2016)

Researchers suggest that NAC supplementation should be considered a treatment option for male infertility