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However, the other co-authors declare no conflicts of interest

Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism

treatment duration is typically a few months (for instance, 3-6 months), although some providers may extend therapy longer for patients who respond well and have no complications

ThDP is used as a cofactor for the microbial enzyme pyruvate-ferredoxin oxidoreductase, which catalyzes the conversion of pyruvate to acetyl-CoA in the pathway for butyrate synthesis (56)