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Exploring the effects of GLP-1 receptor agonists in fibromyalgia: a propensity-matched real-world cohort using the TriNetX research platform

At 72 weeks, a significantly higher proportion of patients receiving orforglipron, particularly the 36 mg dose group (54.6%), achieved and surpassed a clinically meaningful body-weight reduction compared to the placebo group (12.9%) with improvement in cardiometabolic risk factors (Table 1) [32]

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In addition to per-protocol laboratory analyses, human biosamples for future analysis were retained, as long as participants had signed a separate informed consent form

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