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This is a normal physiological response, not a sign that your injection or oral medication has become ineffective

Genome-wide identification of GLP-1 NotchLAG-1 CSL transcriptional targets: ChIP-seq lst-1 and sygl-1 , which were identified in a small candidate gene RNAi screen, are GLP-1 transcriptional targets that are redundantly required for the germline stem cell fate [20,21,42] ( Introduction )

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GLP-1 agonists induce the direct activation of the GLP-1 receptor, leading to the stimulation of pancreatic insulin secretion and the inhibition of glucagon secretion [26]

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