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Maintain your exercise habit at a minimum of 150 minutes per week (200+ is better)

Nausea is the most commonly reported side effect, followed by constipation, stomach pain, diarrhea, fatigue, and vomiting

Evolving therapies for myocardial ischemia/reperfusion injury

These factors should inform shared decision-making between patient and provider, not necessarily contraindicate GLP-1, but justify closer monitoring during dose escalation

Additionally, upregulation of NOX2 has been shown to enhance the anti-pyroptotic and anti-inflammatory effects of metformin