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But the acute peak, the period of maximum cardiovascular change, appears limited to roughly the first six months of treatment
Theoretical concerns regarding pancreatitis and thyroid tumors, observed in animal studies with GLP-1 receptor agonists, warrant ongoing surveillance in human populations
Although promising, this approach remains in the preclinical stage
Together, these findings highlight that while ACE-inhibitory peptides remain the most extensively studied, peptide-based strategies in cardiovascular diseases potentially extend beyond blood pressure regulation to include vascular repair, plaque stabilization, and endothelial modulation
Therefore, HB and MCFAs could both act to upregulate PGC-1, triggering antioxidant response and improving cellular energetics through mitochondrial biogenesis (Figure 2)