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Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway

Common side effects may include: Nausea or upset stomach Diarrhea or constipation Heartburn or acid reflux Fatigue Most of these symptoms are mild to moderate and tend to decrease over time

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Most human studies rely on small sample sizes, short intervention periods, and subjective appetite or liking scales, while lacking objective gustatory measures such as taste-threshold testing or electrogustometry (153, 173, 180, 181)

Ecotoxicol Environ Saf 207:111262