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The wide range of functions within the cell in which glutathione is involved shows that glutathiones role in cellular homeostasis goes beyond being a simple antioxidant agent

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For example, whether renal interstitial fibroblasts, endothelial cells, or immune cell subsets (e.g., M1/M2 macrophages and neutrophils) undergo ferroptosis themselvesand how this cell type-specific ferroptosis contributes to inflammation or fibrosishas not been rigorously characterized

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