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Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

Rats were housed under a 12-hour light/dark cycle with unlimited access to food and water

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This review serves as a valuable resource for researchers aiming to develop new formulations, yet future studies must prioritize rigorous pharmacokinetic evaluations and long-term toxicity profiles to ensure patient safety

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Given that ROS are predominantly generated in mitochondria, excessive OS activation can lead to mitochondrial damage and mitophagy ( 2 combined with Tet on OS, mitochondrial autophagy and apoptosis