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Zepbound also operates by mimicking a hormone that regulates appetite, helping control feelings of hunger and satiety

The SURMOUNT-5 trial published in the New England Journal of Medicine in May 2025 was the first randomized, head-to-head comparison of the two medications in patients with obesity but without type 2 diabetes

However, after a sharp decrease in weight, signs of ptosis show up on the face: The fat layer becomes thinner

Despite this signal, the absolute number of events remained low because NAION is rare

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Comparative analysis revealed that oral administration is more likely to induce gastrointestinal disorders such as pancreatitis, pancreatic cancer, belching, gastric emptying disorders, and gallstones when compared to subcutaneous injection