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Chin J Intern Med 61:13
Nausea and vomiting affect a significant portion of people starting tirzepatide therapy, particularly during dose escalation phases
Testosterone exerts a stimulatory effect on growth hormone secretion at the pituitary level, which is called a push effect. On the other hand, estrogen increases growth hormone secretion only through its inhibitory effect on insulin-like growth factor-I production in the liver with resultant feedback stimulation of growth hormone release from the pituitary: a pull effect (5)
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