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A double-blind study

But when levels are adequate or high, thats when the magic happens

Farhat, Z., Browne, R

If the answer is fat loss, specifically belly fat, tesamorelin is typically the starting recommendation

Association of the SLC19A1 variant rs1051266:G with Wernicke-Korsakoff encephalopathy (125), a condition known to develop due to the thiamine deficiency in the brain, underscores the role of SLC19A1 in delivering not only folate but also thiamine to CNS (28)

[1] [2] Severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with underlying renal impairment