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Duration: Usually resolves within the first month

Venous Stasis: Increased blood viscosity from dehydration slows blood flow, especially in the leg veins, increasing the risk of deep vein thrombosis (DVT) due to venous stasis

While semaglutide demonstrates cardiovascular benefits in patients with established disease (as shown in the SUSTAIN-6 and SELECT trials), the additive tachycardic effect when combined with Adderall may be clinically significant in susceptible individuals, particularly those with pre-existing hypertension, arrhythmias, or structural heart disease

Depending on the severity, surgery may be needed to treat a bowel obstruction

So even at 0.25mg per week, you would need a new vial after week 4 regardless

For most men on TRT with no major health complications, experts typically recommend donating whole blood every 8 to 16 weeks (or 3-6 times per year) to help regulate red cell mass and viscosity