Disconnect between genes associated with ischemic heart disease and targets of ischemic heart disease treatments
This shift from "Large Molecule/Biologic" to "Small Molecule/Chemical" changes everything: Easier Synthesis: They are produced via standard chemical synthesis rather than complex biological fermentation or solid-phase peptide synthesis (SPPS)
Consistent with the electrophysiological recordings, behavioral studies showed that activation of GLP-1R in the ventral hippocampal CA1 regions reduces food intake and body weight, while targeted ventral CA1 GLP-1R knockdown increases food-motivated behaviors (Hsu et al., 2015, 2018)
Additional reported benefits include improved energy, digestion, detoxification, and stronger immunity
it is the result of small, daily choices
J Clin Invest (1995) 96:251520.10.1172/JCI118312 175 KorhonenLSjoholmUTakeiNKernMASchirmacherPCastrenEet alExpression of c-Met in developing rat hippocampus: evidence for HGF as a neurotrophic factor for calbindin D-expressing neurons
