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10.1152/japplphysiol.01070.2010 49 LarsenF

Liew, S.-C., & Gupta, E

General safety considerations from published sources include potential injection site reactions for injectable formats, an initial adjustment period where some individuals report temporary effects, and individual response variation based on numerous factors

Altered gut permeability Patients with coeliac disease have been shown to have an increased frequency [28] and susceptibility to both acute and chronic urticaria with odds ratios of 1.31

The overaccumulation of triacylglycerol and cholesterol in the hepatocytes and the overproduction of reactive oxygen species (ROS) both lead to local inflammatory responses