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"FOXO4 is barely expressed in non-senescent cells, so that makes the peptide interesting as the FOXO4-p53 interaction is especially relevant to senescent cells, but not normal cells," says one of the researchers, Peter de Keizer

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In contrast, sterile water is often used for one-time injections or procedures where additives could be problematic

The easiest approach is using peptides that don't require daily dosing

Ackerman et al., Obesity/Type II diabetes alters macrophage polarization resulting in a fibrotic tendon healing response, PLOS ONE 12, no