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Metabolite concentrations were normalized to the concentration of water calculated from unsuppressed water spectra, since variations in water content within the sample are expected to be much smaller than the variations in the metabolite level [52]

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Whether reducing NNMT activity would directly reverse these changes in humans remains an open research question

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Based on such findings, guideline-directed medical therapy currently recommends SGLT2 inhibitors for people with type 2 diabetes mellitus who are at risk for HF, have pre-HF, or have established HF [92]