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Blekkenhorst, [email protected] This article was submitted to Translational Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Antonucci L, Porcu C, Iannucci G, Balsano C, Barbaro B

Boccardi V, Carino S, Marinelli E, et al

In addition, the severity and duration of the disease are correlated with the level of oxidative stress in the body [7]

Another study reported that, in children with fever, the area under the serum concentration-time curve (AUC) increased by 1344% from first dose to steady state implying that paracetamol may accumulate in this patient group although no hepatotoxicity was demonstrated [48]